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Version: 17.06d (Release date: 2017-06-26)
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Detorubicin (Code C1066)

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Terms & Properties

Preferred Name: Detorubicin

Definition: A semi-synthetic derivative of the anthracycline antineoplastic antibiotic daunorubicin. Detorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation. Detorubicin is less toxic than daunorubicin.

Label: Detorubicin

NCI Thesaurus Code: C1066 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0057578  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Diethoxy-,2-(4-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl)-2-oxoethyl ester,(2S-cis) Acetic Acid

External Source Codes: 
CAS Registry Number 66211-92-5 (see NLM ChemIDplus info)
NSC Code 292652 (see NCI DTP info)
PDQ Closed Trial Search ID 39213
PDQ Open Trial Search ID 39213 (check for NCI PDQ open clinical trial info)
UMLS CUI C0057578

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C33H39NO14
code C1066
Contributing_Source FDA
Legacy_Concept_Name Detorubicin
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  


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