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Version: 17.06d (Release date: 2017-06-26)
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Pembrolizumab (Code C106432)

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Terms & Properties

Preferred Name: Pembrolizumab

Definition: A humanized monoclonal immunoglobulin (Ig) G4 antibody directed against human cell surface receptor PD-1 (programmed death-1 or programmed cell death-1) with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, pembrolizumab binds to PD-1, an inhibitory signaling receptor expressed on the surface of activated T cells, and blocks the binding to and activation of PD-1 by its ligands, which results in the activation of T-cell-mediated immune responses against tumor cells. The ligands for PD-1 include programmed cell death ligand 1 (PD-L1), overexpressed on certain cancer cells, and programmed cell death ligand 2 (PD-L2), which is primarily expressed on APCs. Activated PD-1 negatively regulates T-cell activation and plays a key role in in tumor evasion from host immunity.

Display Name: Pembrolizumab

Label: Pembrolizumab

NCI Thesaurus Code: C106432 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3658706  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Immunoglobulin G4, Anti-(Human Programmed Cell Death 1); Humanized Mouse Monoclonal (228-L-proline(H10-S>P))gamma 4 Heavy Chain (134-218')-disulfide with Humanized Mouse Monoclonal Kappa Light Chain Dimer (226-226'':229-229'')-bisdisulfide
Keytruda
Lambrolizumab
MK-3475
Pembrolizumab
PEMBROLIZUMAB
SCH 900475

External Source Codes: 
CAS Registry Number 1374853-91-4 (see NLM ChemIDplus info)
FDA UNII Code DPT0O3T46P
PDQ Closed Trial Search ID 695789
PDQ Open Trial Search ID 695789 (check for NCI PDQ open clinical trial info)
UMLS CUI C3658706

Other Properties:
     Name Value (qualifiers indented underneath)
code C106432
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C106432

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