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Version: 17.06d (Release date: 2017-06-26)
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Pembrolizumab (Code C106432)

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Terms & Properties

Preferred Name: Pembrolizumab

Definition: A humanized monoclonal immunoglobulin (Ig) G4 antibody directed against human cell surface receptor PD-1 (programmed death-1 or programmed cell death-1) with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, pembrolizumab binds to PD-1, an inhibitory signaling receptor expressed on the surface of activated T cells, and blocks the binding to and activation of PD-1 by its ligands, which results in the activation of T-cell-mediated immune responses against tumor cells. The ligands for PD-1 include programmed cell death ligand 1 (PD-L1), overexpressed on certain cancer cells, and programmed cell death ligand 2 (PD-L2), which is primarily expressed on APCs. Activated PD-1 negatively regulates T-cell activation and plays a key role in in tumor evasion from host immunity.

Display Name: Pembrolizumab

Label: Pembrolizumab

NCI Thesaurus Code: C106432 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3658706  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Immunoglobulin G4, Anti-(Human Programmed Cell Death 1); Humanized Mouse Monoclonal (228-L-proline(H10-S>P))gamma 4 Heavy Chain (134-218')-disulfide with Humanized Mouse Monoclonal Kappa Light Chain Dimer (226-226'':229-229'')-bisdisulfide
SCH 900475

External Source Codes: 
CAS Registry Number 1374853-91-4 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 695789
PDQ Open Trial Search ID 695789 (check for NCI PDQ open clinical trial info)
UMLS CUI C3658706

Other Properties:
     Name Value (qualifiers indented underneath)
code C106432
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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