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Version: 17.06d (Release date: 2017-06-26)
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PBTL CD19CAR-28/CD137/zeta (Code C106429)

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Terms & Properties

Preferred Name: PBTL CD19CAR-28/CD137/zeta

Definition: Peripheral blood T-lymphocytes (PBTLs) transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) consisting of an anti-CD19 scFv (single chain variable fragment) coupled to the costimulatory signaling domain CD28, the signaling domain of 4-1BB (CD137), and the zeta chain of the T-cell receptor (TCR), with potential immunomodulating and antineoplastic activities. Upon transfusion, PBTL CD19CAR-28/CD137zeta directs the T-lymphocytes to CD19-expressing tumor cells and induces selective toxicity in CD19-expressing tumor cells. CD28, a T-cell surface-associated co-stimulatory molecule, is required for full T-cell activation, proliferation, and survival. The 4-1BB co-stimulatory molecule signaling domain enhances activation and signaling after recognition of CD19. Furthermore, inclusion of the 4-1BB signaling domain may increase the antitumor activity compared to the inclusion of the CD28 costimulatory domain and TCR zeta chain alone. CD19 antigen is a B-cell specific cell surface antigen, which is expressed in all B-cell lineage malignancies.

Display Name: PBTL CD19CAR-28/CD137/zeta

Label: PBTL CD19CAR-28/CD137/zeta

NCI Thesaurus Code: C106429 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3831433  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CD19CAR/28137-bearing ATLs
PBTL CD19CAR-28/CD137/zeta

External Source Codes: 
PDQ Closed Trial Search ID 749810
PDQ Open Trial Search ID 749810 (check for NCI PDQ open clinical trial info)
UMLS CUI C3831433

Other Properties:
     Name Value (qualifiers indented underneath)
code C106429
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C106429

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