skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Defibrotide Sodium (Code C1064)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Defibrotide Sodium

Definition: A polydeoxyribonucleotide with antithrombotic, thrombolytic, and fibrinolytic properties. Defibrotide induces the release of prostaglandin 12 and reduces the expression of adhesion molecules on endothelial cells, thereby interfering with platelet and leukocyte adhesion to the endothelium. (NCI04)

NCI-GLOSS Definition: A drug under study for the prevention of veno-occlusive disease, a rare complication of high-dose chemotherapy and stem cell transplantation in which small veins in the liver become blocked.

Display Name: Defibrotide Sodium

Label: Defibrotide Sodium

NCI Thesaurus Code: C1064 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0057257  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Defibrinotide
Defibrotide
defibrotide
DEFIBROTIDE (BOVINE)
Defibrotide Sodium
Defitelio
Fraction P
Noravid
Prociclide

External Source Codes: 
CAS Registry Number 83712-60-1 (see NLM ChemIDplus info)
FDA UNII Code 438HCF2X0M
PDQ Closed Trial Search ID 43522
PDQ Open Trial Search ID 43522 (check for NCI PDQ open clinical trial info)
UMLS CUI C0057257

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Thrombotic thrombocytopenic purpura
code C1064
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Defibrotide
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1064

Mainbox Bottom