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Version: 17.06d (Release date: 2017-06-26)
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c-Met Inhibitor MSC2156119J (Code C106370)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: c-Met Inhibitor MSC2156119J

Definition: An orally bioavailable inhibitor of the proto-oncogene c-Met (also known as hepatocyte growth factor receptor (HGFR)) with potential antineoplastic activity. c-Met inhibitor MSC2156119J selectively binds to c-Met, which inhibits c-Met phosphorylation and disrupts c-Met-mediated signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays key roles in tumor cell proliferation, survival, invasion, metastasis, and tumor angiogenesis.

Display Name: c-Met Inhibitor MSC2156119J

Label: c-Met Inhibitor MSC2156119J

NCI Thesaurus Code: C106370 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL447736  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
c-Met Inhibitor MSC2156119J
MSC2156119J

External Source Codes: 
PDQ Closed Trial Search ID 749525
PDQ Open Trial Search ID 749525 (check for NCI PDQ open clinical trial info)
NCI META CUI CL447736

Other Properties:
     Name Value (qualifiers indented underneath)
code C106370
Contributing_Source CTRP
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C106370

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