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Version: 17.06d (Release date: 2017-06-26)
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Simmitecan Hydrochloride (Code C106369)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Simmitecan Hydrochloride

Definition: The hydrochloride salt form of simmitecan, an ester prodrug of chimmitecan, a 9-alkyl substituted camptothecin derivative with potential antineoplastc activity. Upon intravenous administration, simmitecan is hydrolyzed by carboxylesterase and the activated form, chimmitecan, is produced. Chimmitecan inhibits topoisomerase I, stabilizes covalent topoisomerase I-DNA complexes, and inhibits the religation of topoisomerase I-mediated single-strand DNA breaks. Futhermore, the covalent topoisomerase I-DNA complexes interfere and block the DNA replication machinery, resulting in the production of potentially lethal double-strand DNA breaks. This leads to an inhibition of DNA replication and the induction of apoptosis. The modification at position 9 yields improved cytotoxicity compared to some other camptothecin analogues.

Label: Simmitecan Hydrochloride

NCI Thesaurus Code: C106369 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL447735  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Simmitecan Hydrochloride

External Source Codes: 
PDQ Closed Trial Search ID 749475
PDQ Open Trial Search ID 749475 (check for NCI PDQ open clinical trial info)
NCI META CUI CL447735

Other Properties:
     Name Value (qualifiers indented underneath)
code C106369
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C106369

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