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Version: 17.06d (Release date: 2017-06-26)
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S1P Receptor Agonist KRP203 (Code C106368)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: S1P Receptor Agonist KRP203

Definition: The hydrochloride salt form of 2-amino-2 propanediol (KRP-203), a sphingosine 1-phosphate (S1P) receptor agonist, with potential immunosuppressive activity. Upon administration of S1P receptor agonist KRP203, this agent binds to S1P receptors on lymphocytes, which prevents binding of serum S1P to S1P receptors and leads to S1P receptor internalization. This reduces the number of circulating blood leukocytes and accelerates lymphocyte homing into peripheral lymph nodes, thereby preventing their infiltration into peripheral inflammatory sites. This agent also decreases the production of inflammatory cytokines by lymphocytes, such as interferon gamma (IFN-g), interleukin-12 (IL-12), and tumor necrosis factor (TNF).

Label: S1P Receptor Agonist KRP203

NCI Thesaurus Code: C106368 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1570777  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-Amino-2-propanediol Hydrochloride
KRP-203
KRP203
S1P Receptor Agonist KRP203

External Source Codes: 
PDQ Closed Trial Search ID 749378
PDQ Open Trial Search ID 749378 (check for NCI PDQ open clinical trial info)
UMLS CUI C1570777

Other Properties:
     Name Value (qualifiers indented underneath)
code C106368
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C106368

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