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Version: 17.06d (Release date: 2017-06-26)
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Liposome-encapsulated RB94 Plasmid DNA Gene Therapy Agent SGT-94 (Code C106271)

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Terms & Properties

Preferred Name: Liposome-encapsulated RB94 Plasmid DNA Gene Therapy Agent SGT-94

Definition: A systemic gene therapy anti-cancer agent composed of cationic liposomes, which encapsulates plasmid DNA encoding for the tumor suppressor gene RB94 and is complexed with anti-transferrin receptor single chain antibody fragment (TfRscFv), with potential antineoplastic activity. Upon systemic administration of liposome-encapsulated RB94 plasmid DNA gene therapy agent SGT-94, the TfRscFv portion of this agent selectively targets the tumor cells expressing transferrin receptors. TfRscFv binding to the transferrin receptor allows receptor-mediated endocytosis and transfection, followed by the expression of RB94 gene. This induces tumor cell apoptosis through an as of yet unknown pathway. RB94 is a modified, N-terminal truncated form of the full-length protein retinoblastoma gene RB110, and exerts enhanced antitumor activity. The transferrin receptor (TfR) functions in cellular iron uptake through its interaction with transferrin, and is overexpressed in a variety of tumor types.

Display Name: Liposome-encapsulated RB94 Plasmid DNA Gene Therapy Agent SGT-94

Label: Liposome-encapsulated RB94 Plasmid DNA Gene Therapy Agent SGT-94

NCI Thesaurus Code: C106271 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL433963  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Liposome-encapsulated RB94 Plasmid DNA Gene Therapy Agent SGT-94
SGT-94
TfRscFv/Lip/RB94

External Source Codes: 
PDQ Closed Trial Search ID 724243
PDQ Open Trial Search ID 724243 (check for NCI PDQ open clinical trial info)
NCI META CUI CL433963

Other Properties:
     Name Value (qualifiers indented underneath)
code C106271
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C106271

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