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Version: 17.06d (Release date: 2017-06-26)
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Brachyury-expressing Yeast Vaccine GI-6301 (Code C106267)

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Terms & Properties

Preferred Name: Brachyury-expressing Yeast Vaccine GI-6301

Definition: A cancer vaccine composed of a heat-killed, recombinant form of the yeast Saccharomyces cerevisiae that is genetically modified to express the transcription factor brachyury protein, with potential antineoplastic activity. Upon subcutaneous administration, the brachyury-expressing yeast vaccine GI-6301 is recognized by dendritic cells, processed, and presented by Class I and II MHC molecules on the dendritic cell surface. This elicits a targeted CD4+ and CD8+ T-lymphocyte-mediated immune response. This process kills brachyury-expressing tumor cells. Brachyury is overexpressed in a variety of tumor types and plays an important role in cancer progression and metastasis.

Display Name: Brachyury-expressing Yeast Vaccine GI-6301

Label: Brachyury-expressing Yeast Vaccine GI-6301

NCI Thesaurus Code: C106267 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL433965  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Brachyury-expressing Yeast Vaccine GI-6301

External Source Codes: 
PDQ Closed Trial Search ID 724520
PDQ Open Trial Search ID 724520 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C106267
Contributing_Source CTRP
Semantic_Type Immunologic Factor
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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