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Version: 17.06d (Release date: 2017-06-26)
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pan-RAF Kinase Inhibitor TAK-580 (Code C106254)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: pan-RAF Kinase Inhibitor TAK-580

Definition: An orally available inhibitor of A-Raf, B-Raf and C-Raf protein kinases, with potential antineoplastic activity. Upon administration, pan-RAF kinase inhibitor TAK-580 inhibits Raf-mediated signal transduction pathways, which may lead to an inhibition of tumor cell growth. Raf protein kinases play a key role in the RAF/MEK/ERK signaling pathway, which is often deregulated in human cancers and plays a key role in tumor cell proliferation and survival.

Display Name: pan-RAF Kinase Inhibitor TAK-580

Label: pan-RAF Kinase Inhibitor TAK-580

NCI Thesaurus Code: C106254 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL433881  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(R)-2-(1-(6-amino-5-chloropyrimidine-4-carboxamido)ethyl)-N-(5-chloro-4-(trifluoromethyl)pyridin-2-yl)thiazole-5-carboxamide
BIIB-024
MLN-2480
MLN2480
pan-RAF Kinase Inhibitor TAK-580
TAK-580
TAK580

External Source Codes: 
CAS Registry Number 1096708-71-2 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 710688
PDQ Open Trial Search ID 710688 (check for NCI PDQ open clinical trial info)
NCI META CUI CL433881

Other Properties:
     Name Value (qualifiers indented underneath)
code C106254
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C106254

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