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Version: 17.06d (Release date: 2017-06-26)
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Selective Estrogen Receptor Degrader ARN-810 (Code C106235)

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Terms & Properties

Preferred Name: Selective Estrogen Receptor Degrader ARN-810

Definition: An orally available, nonsteroidal selective estrogen receptor degrader (SERD), with potential antineoplastic activity. Upon oral administration, SERD ARN-810 binds to the estrogen receptor and induces a conformational change that results in the degradation of the receptor. This may inhibit the growth and survival of ER-expressing cancer cells.

Display Name: Selective Estrogen Receptor Degrader ARN-810

Label: Selective Estrogen Receptor Degrader ARN-810

NCI Thesaurus Code: C106235 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL447410  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ARN-810
GDC-0810
RO7056118
Selective Estrogen Receptor Degrader ARN-810
SERD ARN-810

External Source Codes: 
PDQ Closed Trial Search ID 748900
PDQ Open Trial Search ID 748900 (check for NCI PDQ open clinical trial info)
NCI META CUI CL447410

Other Properties:
     Name Value (qualifiers indented underneath)
code C106235
Contributing_Source CTRP
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C106235

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