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Version: 17.06d (Release date: 2017-06-26)
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MEK/Aurora Kinase Inhibitor BI 847325 (Code C106126)

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Terms & Properties

Preferred Name: MEK/Aurora Kinase Inhibitor BI 847325

Definition: An orally available dual inhibitor of mitogen-activated protein kinase kinase (MEK) and Aurora kinases, with potential antineoplastic activity. Upon oral administration, MEK/Aurora kinase inhibitor BI 847325 selectively binds to and inhibits the activity of MEK, which both prevents the activation of MEK-dependent effector proteins and inhibits growth factor-mediated cell signaling. BI 847325 also binds to and inhibits the activity of the Aurora kinases A, B and C which may disrupt the assembly of the mitotic spindle apparatus, prevent chromosome segregation, and inhibit both cellular division and proliferation in Aurora kinase-overexpressing tumor cells. Altogether, this leads to the inhibition of cell proliferation and tumor growth as well as the induction of tumor regression. MEK, a dual-specificity threonine/tyrosine kinase that plays a key role in the activation of the RAS/RAF/MEK/ERK signaling pathway, is frequently upregulated in a variety of tumor cell types. Aurora kinases are serine-threonine kinases that play essential roles in mitotic checkpoint control and are overexpressed by a wide variety of cancer cell types.

Label: MEK/Aurora Kinase Inhibitor BI 847325

NCI Thesaurus Code: C106126 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL433815  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
BI 847325
MEK/Aurora Kinase Inhibitor BI 847325

External Source Codes: 
PDQ Closed Trial Search ID 698315
PDQ Open Trial Search ID 698315 (check for NCI PDQ open clinical trial info)
NCI META CUI CL433815

Other Properties:
     Name Value (qualifiers indented underneath)
code C106126
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C106126

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