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Version: 17.06d (Release date: 2017-06-26)
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iC9-GD2-CD28-OX40-expressing T Lymphocytes (Code C106123)

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Terms & Properties

Preferred Name: iC9-GD2-CD28-OX40-expressing T Lymphocytes

Definition: Modified T-lymphocytes expressing a 3rd generation chimeric antigen receptor (CAR) specific for the disialoganglioside GD2, which contains the CD3zeta chain, the signaling domains of the co-stimulatory molecules CD28 and CD134 (OX-40) and the suicide gene inducible caspase 9 (iCasp9), with potential immunomodulating and antineoplastic activities. Upon administration, iC9-GD2-CD28-OX40-expressing T lymphocytes target the GD2 antigen on tumor cells, thereby providing selective toxicity towards GD2-expressing tumor cells. iCasp9 consists of a human FK506 drug-binding domain with an F36V mutation (FKBP12-F36V) linked to human caspase 9. If the administered T cells lead to unacceptable side effects, the chemical homodimerizer AP1903 can be administered, which binds to the drug binding FKBP12-F36V domain and activates caspase 9, resulting in the apoptosis of the administered T-cells. The tumor associated antigen GD2 is overexpressed on the surface of almost all tumors of neuroectodermal origin. OX40 and CD28, both T-cell surface-associated co-stimulatory molecules, are required for full T-cell activation.

Display Name: iC9-GD2-CD28-OX40-expressing T Lymphocytes

Label: iC9-GD2-CD28-OX40-expressing T Lymphocytes

NCI Thesaurus Code: C106123 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL447359  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
iC9-GD2-CD28-OX40-expressing T Lymphocytes
iC9-GD2 T Lymphocytes

External Source Codes: 
PDQ Closed Trial Search ID 748767
PDQ Open Trial Search ID 748767 (check for NCI PDQ open clinical trial info)
NCI META CUI CL447359

Other Properties:
     Name Value (qualifiers indented underneath)
code C106123
Contributing_Source CTRP
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C106123

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