skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Glutathione Pegylated Liposomal Doxorubicin Hydrochloride Formulation 2B3-101 (Code C106121)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Glutathione Pegylated Liposomal Doxorubicin Hydrochloride Formulation 2B3-101

Definition: A glutathione (GSH) pegylated, liposome-encapsulated preparation of the hydrochloride salt form of the anthracycline antineoplastic antibiotic doxorubicin, with potential anetineoplastic activity. Upon administration, the glutathione pegylated liposomal formulation 2B3-101 specifically delivers doxorubicin into the brain. Doxorubicin intercalates between DNA base pairs and interferes with topoisomerase II activity, which inhibits both DNA replication and RNA synthesis, resulting in cancer cell death and tumor regression. Doxorubicin also generates reactive oxygen species, which causes cell membrane lipid peroxidation leading to cytotoxicity. The pegylated liposomal delivery of doxorubicin improves drug penetration into tumors and prolongs circulation time, thereby increasing doxorubicin's efficacy and decreasing its toxicity. Conjugation of GSH to the PEG molecules directs the liposomes to the GSH transporters on the blood brain barrier (BBB) and improves the delivery of doxorubicin into the brain.

Label: Glutathione Pegylated Liposomal Doxorubicin Hydrochloride Formulation 2B3-101

NCI Thesaurus Code: C106121 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3827174  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2B3-101
Glutathione Pegylated Liposomal Doxorubicin Hydrochloride Formulation 2B3-101

External Source Codes: 
PDQ Closed Trial Search ID 748730
PDQ Open Trial Search ID 748730 (check for NCI PDQ open clinical trial info)
UMLS CUI C3827174

Other Properties:
     Name Value (qualifiers indented underneath)
code C106121
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C106121

Mainbox Bottom