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Version: 17.06d (Release date: 2017-06-26)
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p53-HDM2 Interaction Inhibitor MI-773 (Code C106120)

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Terms & Properties

Preferred Name: p53-HDM2 Interaction Inhibitor MI-773

Definition: An orally available spiro-oxindole HDM2 (human double minute 2) antagonist with potential antineoplastic activity. Upon oral administration, the p53-HDM2 protein-protein interaction inhibitor MI-773 binds to HDM2, preventing the binding of the HDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this HDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited and the transcriptional activity of p53 is restored, which may result in the restoration of p53 signaling and lead to the p53-mediated induction of tumor cell apoptosis. HDM2, a zinc finger protein and a negative regulator of the p53 pathway, is often overexpressed in cancer cells. It has been implicated in cancer cell proliferation and survival.

Display Name: p53-HDM2 Interaction Inhibitor MI-773

Label: p53-HDM2 Interaction Inhibitor MI-773

NCI Thesaurus Code: C106120 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3853940  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
MI-773
p53-HDM2 Interaction Inhibitor MI-773
p53-MDM2 Interaction Inhibitor MI-773
SAR405838

External Source Codes: 
PDQ Closed Trial Search ID 737146
PDQ Open Trial Search ID 737146 (check for NCI PDQ open clinical trial info)
UMLS CUI C3853940

Other Properties:
     Name Value (qualifiers indented underneath)
code C106120
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C106120

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