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Version: 17.06d (Release date: 2017-06-26)
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T1E28z CAR-expressing Autologous CD4-positive T Lymphocytes (Code C106117)

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Terms & Properties

Preferred Name: T1E28z CAR-expressing Autologous CD4-positive T Lymphocytes

Definition: Autologous CD4 positive T-lymphocytes engineered to express the chimeric antigen receptor (CAR) T1E28z containing the ErbB ligand, T1E, fused to the hinge region, transmembrane domain and endodomain of CD28 and the CD3zeta endodomain, with potential immunomodulating and antineoplastic activities. T1E, a chimeric polypeptide containing the N-terminus of human transforming growth factor (TGF)-alpha fused to the C-terminus of epidermal growth factor (EGF), binds to ErbB1 homodimers and heterodimers as well as ErbB2/3 heterodimers, but not to ErbB2 or erbB3 alone. Upon intratumoral administration, the promiscuous ErbB ligand T1E of the T1E28z CAR-expressing autologous CD4-positive T lymphocytes binds to the specific ErbB homo- and heterodimers on tumor cells. This induces selective toxicity in ErbB-expressing tumor cells resulting in tumor cell lysis. ErbB1, ErbB2 and ErbB3, members of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases, are frequently overexpressed in solid tumors and play key roles in tumor cell proliferation and tumor angiogenesis.

Label: T1E28z CAR-expressing Autologous CD4-positive T Lymphocytes

NCI Thesaurus Code: C106117 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL447356  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4ab T1E28z Positive T-cells
T1E28z CAR-expressing Autologous CD4-positive T Lymphocytes

External Source Codes: 
PDQ Closed Trial Search ID 748623
PDQ Open Trial Search ID 748623 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C106117
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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