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Version: 17.06d (Release date: 2017-06-26)
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CDK/JAK2/FLT3 Inhibitor TG02 Citrate (Code C105851)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: CDK/JAK2/FLT3 Inhibitor TG02 Citrate

Definition: An orally bioavailable citrate salt form of TG02, a multi-kinase inhibitor for cyclin dependent kinase (CDK) subtypes 1, 2, 7 and 9, Janus-associated kinase 2 (JAK2), FMS-related tyrosine kinase 3 (FLT3, FLK2, STK1), with potential antineoplastic activity. Upon oral administration, CDK/JAK2/FLT3 Inhibitor TG02 binds to and inhibits the CDK subtypes, JAK2, and FLT3. TG02 also inhibits, to a lesser extent, TYK2, TYRO3, STAT5 and P38delta. This may result in both an induction of apoptosis and an inhibition of tumor cell proliferation in cancer cells that overexpress these kinases. JAK2, often upregulated or mutated in a variety of cancer cells, mediates STAT3 activation and plays a key role in tumor cell proliferation and survival. CDKs are serine/threonine kinases that play key roles in the regulation of the cell cycle and cellular proliferation. FLT3, a class III tyrosine kinase receptor, is overexpressed or mutated in most B lineage and acute myeloid leukemias.

Display Name: CDK/JAK2/FLT3 Inhibitor TG02 Citrate

Label: CDK/JAK2/FLT3 Inhibitor TG02 Citrate

NCI Thesaurus Code: C105851 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL447179  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CDK/JAK2/FLT3 Inhibitor TG02 Citrate
SB1317 Citrate
TG02 Citrate

External Source Codes: 
PDQ Closed Trial Search ID 686272
PDQ Open Trial Search ID 686272 (check for NCI PDQ open clinical trial info)
NCI META CUI CL447179

Other Properties:
     Name Value (qualifiers indented underneath)
code C105851
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C105851

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