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Version: 17.06d (Release date: 2017-06-26)
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[18F]L-FMAC (Code C105850)

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Terms & Properties

Preferred Name: [18F]L-FMAC

Definition: A radioconjugate composed of 2'-deoxy-2'-18F-fluoro-5-methyl-beta-L-arabinofuranosylcytosine ([18F]L-FMAC), a L-deoxycytidine analog and high-affinity substrate for deoxycytidine kinase (DCK), labeled with fluorine F 18, with potential diagnostic activity during positron emission tomography (PET) imaging. Upon administration, [18F]L-FMAC is preferentially taken up by and accumulated in cells with high DCK levels, including tumor cells with dysregulated nucleoside metabolism. After phosphorylation by DCK, the 18F moiety can be visualized by PET imaging. As many nucleoside analog prodrugs are chemotherapeutic agents that require DCK for their phosphorylation and activation, [18F]L-FMAC can potentially be used as a marker to measure DCK activity and to predict the chemotherapeutic efficacy of DCK-dependent prodrugs. DCK, a rate-limiting enzyme in the deoxyribonucleoside salvage pathway for DNA synthesis, is overexpressed in certain solid tumors, lymphoid and myeloid malignancies and certain immune cells, such as proliferating T-lymphocytes. The L-enantiomer is less susceptible to deamination by cytidine deaminase (CDA) than the D-enantiomer and increases the stability of this radioconjugate.

Display Name: [18F]L-FMAC

Label: [18F]L-FMAC

NCI Thesaurus Code: C105850 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL447178  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2'-Deoxy-2'-18F-fluoro-5-methyl-beta-L-arabinofuranosylcytosine
[18F]L-FMAC
L-fluorine F 18-FMAC
L-FMAC F-18

External Source Codes: 
CAS Registry Number 1134848-13-7 (see NLM ChemIDplus info)
FDA UNII Code 1550OGY7TD
PDQ Closed Trial Search ID 748182
PDQ Open Trial Search ID 748182 (check for NCI PDQ open clinical trial info)
NCI META CUI CL447178

Other Properties:
     Name Value (qualifiers indented underneath)
code C105850
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Chemical
Semantic_Type Indicator, Reagent, or Diagnostic Aid

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C105850

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