skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Ad-hCMV-Flt3L (Code C105813)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Ad-hCMV-Flt3L

Definition: A human serotype 5, replication-defective, first generation adenoviral vector, with the viral E1a and E3 protein encoding regions deleted, which is engineered to express the soluble, immune-mediated stimulatory gene human fms-like tyrosine kinase 3 ligand (Flt3L), under the transcriptional control of the CMV promoter, with potential immunostimulating activity. Upon administration, Ad-hCMV-Flt3L is transduced into tumor cells and Flt3L is expressed. Flt3L stimulates both the proliferation of dendritic cells (DCs) and their migration to the tumor site. Upon exposure to the tumor-associated antigens (TAA) released from dying glioma cells, which were killed by thymidine kinase-mediated valacyclovir-induced tumor cell death, the DCs initiate a specific immune response against any remaining TAA-expressing tumor cells. Flt3L is a hematopoietic growth factor and ligand for the Flt3 tyrosine kinase receptor.

Display Name: Ad-hCMV-Flt3L

Label: Ad-hCMV-Flt3L

NCI Thesaurus Code: C105813 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL447164  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Ad-hCMV-Flt3L

External Source Codes: 
PDQ Closed Trial Search ID 747933
PDQ Open Trial Search ID 747933 (check for NCI PDQ open clinical trial info)
NCI META CUI CL447164

Other Properties:
     Name Value (qualifiers indented underneath)
code C105813
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C105813

Mainbox Bottom