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Version: 17.06d (Release date: 2017-06-26)
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Ad-hCMV-TK (Code C105811)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Ad-hCMV-TK

Definition: A human serotype 5, replication-defective, first generation adenoviral vector, with the viral E1a and E3 protein encoding regions deleted, which is engineered to express the herpes simplex virus thymidine kinase (HSV-tk) gene under the transcriptional control of the CMV promoter. This agent, when administered in conjunction with a synthetic acyclic guanosine analogue, possesses potential antineoplastic activity. Upon administration into the peritumoral region after tumor resection, adenoviral vector encoding HSV thymidine kinase is transduced into tumor cells, and HSV-tk is expressed. Tumor cells expressing HSV-tk are sensitive to synthetic acyclic guanosine analogues. Subsequent administration of a synthetic acyclic guanosine analogue, such as valacyclovir (VCV) or ganciclovir (GCV), kills the tumor cells expressing HSV-tk. The release of tumor-associated antigens (TAA) by dying tumor cells may then stimulate an antitumor cytotoxic T lymphocyte (CTL) response, directed aganst any remaining tumor cells.

Display Name: Ad-hCMV-TK

Label: Ad-hCMV-TK

NCI Thesaurus Code: C105811 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL447163  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Ad-hCMV-TK

External Source Codes: 
PDQ Closed Trial Search ID 747932
PDQ Open Trial Search ID 747932 (check for NCI PDQ open clinical trial info)
NCI META CUI CL447163

Other Properties:
     Name Value (qualifiers indented underneath)
code C105811
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C105811

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