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Version: 17.06d (Release date: 2017-06-26)
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Indium In 111 Pertuzumab (Code C105808)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Indium In 111 Pertuzumab

Definition: A radioimmunoconjugate composed of a humanized recombinant monoclonal antibody directed against the extracellular dimerization domain of the tyrosine kinase receptor human epidermal growth factor-2 (HER-2) and linked to the gamma-emitting radioisotope indium In 111, with potential use in radioimaging. Upon administration, indium In 111 pertuzumab binds to HER-2. After binding and internalization into HER-2-expressing tumor cells, radioactive In 111 facilitates the detection of HER-2-expressing tumor cells using single photon emission computed tomography (SPECT). This may predict or evaluate the tumor's response to certain HER-2-targeting chemotherapeutics.

Label: Indium In 111 Pertuzumab

NCI Thesaurus Code: C105808 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL447160  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
111In-pertuzumab
Indium In 111 Pertuzumab

External Source Codes: 
PDQ Closed Trial Search ID 747741
PDQ Open Trial Search ID 747741 (check for NCI PDQ open clinical trial info)
NCI META CUI CL447160

Other Properties:
     Name Value (qualifiers indented underneath)
code C105808
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Indicator, Reagent, or Diagnostic Aid

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C105808

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