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Version: 17.12d (Release date: 2017-12-26)
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Fms/Trk Tyrosine Kinase Inhibitor PLX7486 Tosylate (Code C105804)

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Terms & Properties

Preferred Name: Fms/Trk Tyrosine Kinase Inhibitor PLX7486 Tosylate

Definition: The tosylate salt form of PLX7486, a selective inhibitor of the receptor tyrosine kinases colony-stimulating factor-1 receptor (CSF1R; fms) and neurotrophic tyrosine kinase receptor types 1, 2 and 3 (TrkA, TrkB, and TrkC, respectively) with potential antineoplastic activity. Upon administration, PLX7486 binds to and inhibits the activity of these tyrosine kinases. This inhibits Fms and Trk-mediated signaling transduction pathways that are upregulated in certain cancer cell types. This may eventually halt tumor cell proliferation in Fms and TrkA, TrkB, and/or TrkC-overexpressing tumor cells. Fms and TrkA, TrkB, and TrkC are receptor tyrosine kinases that are upregulated or mutated in a variety of tumors and promote tumor cell proliferation and survival.

Display Name: Fms/Trk Tyrosine Kinase Inhibitor PLX7486 Tosylate

Label: Fms/Trk Tyrosine Kinase Inhibitor PLX7486 Tosylate

NCI Thesaurus Code: C105804 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3830093  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Fms/Trk Tyrosine Kinase Inhibitor PLX7486 Tosylate

External Source Codes: 
PDQ Closed Trial Search ID 747694
PDQ Open Trial Search ID 747694 (check for NCI PDQ open clinical trial info)
UMLS CUI C3830093

Other Properties:
     Name Value (qualifiers indented underneath)
code C105804
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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