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Version: 17.06d (Release date: 2017-06-26)
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Liposome-encapsulated miR-34 Mimic MRX34 (Code C105802)

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Terms & Properties

Preferred Name: Liposome-encapsulated miR-34 Mimic MRX34

Definition: A liposomal formulation containing a nucleotide that mimics the human tumor suppressor microRNA (miRNA) miR-34, with potential antineoplastic activity. Upon administration, liposome-encapsulated MRX34 mimics miR-34 by inhibiting the expression of a variety of oncogenes including MYC, MET, BCL2, and beta-catenin. This induces cell cycle arrest, senescence and apoptosis in susceptible tumor cells. miR-34 is downregulated in most solid and hematologic malignancies and regulates the expression of a variety of genes. This miRNA plays an important role in the inhibition of cancer cell stemness, metastasis and cancer cell survival.

Display Name: Liposome-encapsulated miR-34 Mimic MRX34

Label: Liposome-encapsulated miR-34 Mimic MRX34

NCI Thesaurus Code: C105802 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL447293  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Liposome-encapsulated miR-34 Mimic MRX34
MRX34

External Source Codes: 
PDQ Closed Trial Search ID 747643
PDQ Open Trial Search ID 747643 (check for NCI PDQ open clinical trial info)
NCI META CUI CL447293

Other Properties:
     Name Value (qualifiers indented underneath)
code C105802
Contributing_Source CTRP
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C105802

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