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Version: 17.06d (Release date: 2017-06-26)
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ALK Inhibitor RO5424802 (Code C105615)

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Terms & Properties

Preferred Name: ALK Inhibitor RO5424802

Definition: An orally available inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with antineoplastic activity. Upon administration, ALK inhibitor RO5424802 binds to and inhibits ALK kinase, which leads to a disruption of ALK-mediated signaling and eventually inhibits tumor cell growth in ALK-overexpressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. ALK dysregulation and gene rearrangements are associated with a series of tumors. Additionally, ALK mutations are associated with acquired resistance to small molecule tyrosine kinase inhibitors.

Display Name: ALK Inhibitor RO5424802

Label: ALK Inhibitor RO5424802

NCI Thesaurus Code: C105615 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL446452  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ALK Inhibitor RO5424802
RO5424802

External Source Codes: 
PDQ Closed Trial Search ID 747398
PDQ Open Trial Search ID 747398 (check for NCI PDQ open clinical trial info)
NCI META CUI CL446452

Other Properties:
     Name Value (qualifiers indented underneath)
code C105615
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C105615

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