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Version: 17.06d (Release date: 2017-06-26)
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Gemcitabine Hydrochloride Emulsion (Code C105613)

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Terms & Properties

Preferred Name: Gemcitabine Hydrochloride Emulsion

Definition: An orally available nanoparticle-based formulation containing the hydrochloride salt form of gemcitabine, a broad-spectrum antimetabolite and deoxycytidine analogue, with antineoplastic activity. The formulation consists of an oil-in-water emulsion in which gemicitabine is solubilized in the excipient matrix containing a mixture of oil and (co)surfactants. Upon oral administration, gemcitabine is converted into the active metabolites difluorodeoxycytidine diphosphate (dFdCDP) and difluorodeoxycytidine triphosphate (dFdCTP) by deoxycytidine kinase. dFdCTP competes with deoxycytidine triphosphate (dCTP) and is incorporated into DNA, resulting in premature termination of DNA replication and the induction of apoptosis. Further, dFdCDP inhibits ribonucleotide reductase and reduces the deoxynucleotide pool available for DNA synthesis. Compared to gemcitabine alone, the emulsion allows for increased oral bioavailability and decreases its susceptibility to deamination and deactivation by cytidine deaminase.

Label: Gemcitabine Hydrochloride Emulsion

NCI Thesaurus Code: C105613 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL446450  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
D07001-F4
Gemcitabine Hydrochloride Emulsion

External Source Codes: 
PDQ Closed Trial Search ID 747250
PDQ Open Trial Search ID 747250 (check for NCI PDQ open clinical trial info)
NCI META CUI CL446450

Other Properties:
     Name Value (qualifiers indented underneath)
code C105613
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C105613

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