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National Cancer Institute
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Version: 17.12d (Release date: 2017-12-26)
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EGFR Inhibitor ABT-414 (Code C105612)

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Terms & Properties

Preferred Name: EGFR Inhibitor ABT-414

Definition: An epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity. Upon intravenous infusion, ABT-414 inhibits the activity of EGFR, thereby preventing EGFR-mediated signaling. This may inhibit tumor growth in EGFR-overexpressing tumor cells. EGFR, a receptor tyrosine kinase overexpressed in certain tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization.

Display Name: EGFR Inhibitor ABT-414

Label: EGFR Inhibitor ABT-414

NCI Thesaurus Code: C105612 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL446449  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
EGFR Inhibitor ABT-414

External Source Codes: 
PDQ Closed Trial Search ID 747249
PDQ Open Trial Search ID 747249 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C105612
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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