skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
EGFR Inhibitor ABT-414 (Code C105612)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: EGFR Inhibitor ABT-414

Definition: An epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity. Upon intravenous infusion, ABT-414 inhibits the activity of EGFR, thereby preventing EGFR-mediated signaling. This may inhibit tumor growth in EGFR-overexpressing tumor cells. EGFR, a receptor tyrosine kinase overexpressed in certain tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization.

Display Name: EGFR Inhibitor ABT-414

Label: EGFR Inhibitor ABT-414

NCI Thesaurus Code: C105612 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL446449  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ABT-414
EGFR Inhibitor ABT-414

External Source Codes: 
PDQ Closed Trial Search ID 747249
PDQ Open Trial Search ID 747249 (check for NCI PDQ open clinical trial info)
NCI META CUI CL446449

Other Properties:
     Name Value (qualifiers indented underneath)
code C105612
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C105612

Mainbox Bottom