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Version: 17.06d (Release date: 2017-06-26)
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Entospletinib (Code C105402)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Entospletinib

Definition: An orally available inhibitor of spleen tyrosine kinase (Syk), with potential antineoplastic activity. Upon oral administration of entospletinib, this agent may inhibit the activity of Syk, which inhibits B-cell receptor (BCR) signaling and leads to an inhibition of tumor cell activation, migration, adhesion and proliferation. Syk, a non-receptor cytoplasmic, BCR-associated tyrosine kinase, is expressed in hematopoietic tissues and is often overexpressed in hematopoeitic malignancies.

Display Name: Entospletinib

Label: Entospletinib

NCI Thesaurus Code: C105402 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3642151  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
6-(1H-Indazol-6-yl)-N-(4-(morpholin-4-yl)phenyl)imidazo(1,2-a)pyrazin-8-amine
ENTO
Entospletinib
ENTOSPLETINIB
GS-9973
GS 9973
Imidazo(1,2-a)pyrazin-8-amine, 6-(1H-indazol-6-yl)-N-(4-(4-morpholinyl)phenyl)-

External Source Codes: 
CAS Registry Number 1229208-44-9 (see NLM ChemIDplus info)
FDA UNII Code 6I3O3W6O3B
PDQ Closed Trial Search ID 746910
PDQ Open Trial Search ID 746910 (check for NCI PDQ open clinical trial info)
UMLS CUI C3642151

Other Properties:
     Name Value (qualifiers indented underneath)
code C105402
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C105402

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