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Version: 17.06d (Release date: 2017-06-26)
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2-Hydroxyoleic Acid (Code C105401)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: 2-Hydroxyoleic Acid

Definition: An orally bioavailable, synthetic analog of the fatty acid oleic acid, with potential antitumor activity. Upon administration, 2-hydroxyoleic acid (2OHOA) activates sphingomyelin synthase (SMS), thereby increasing the concentration of sphingomyelin (SM) and diacylglycerol (DAG) in the tumor cell membrane and decreasing membrane levels of phosphatidylethanolamine (PE) and phosphatidylcholine (PC). This restores the normal, healthy levels and ratios of membrane lipids. By restoring normal membrane lipid structure and composition, this agent inhibits membrane-protein associated signaling and the aberrant activity of signaling pathways in certain tumor cells, including the Ras/MAPK and PI3K/AKt pathways. This inhibits tumor cell proliferation, induces tumor cell differentiation, and eventually can cause cell death.

Label: 2-Hydroxyoleic Acid

NCI Thesaurus Code: C105401 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1566317  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-Hydroxyoleic Acid
2-OHOA
2OHOA
Minerval

External Source Codes: 
PDQ Closed Trial Search ID 746793
PDQ Open Trial Search ID 746793 (check for NCI PDQ open clinical trial info)
UMLS CUI C1566317

Other Properties:
     Name Value (qualifiers indented underneath)
code C105401
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C105401

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