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Version: 17.06d (Release date: 2017-06-26)
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Clarithromycin (Code C1054)

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Terms & Properties

Preferred Name: Clarithromycin

Definition: A semisynthetic 14-membered ring macrolide antibiotic. Clarithromycin binds to the 50S ribosomal subunit and inhibits RNA-dependent protein synthesis in susceptible organisms. Clarithromycin has been shown to eradicate gastric MALT (mucosa-associated lymphoid tissue) lymphomas, presumably due to the eradication of tumorigenic Helicobacter pylori infection. This agent also acts as a biological response modulator, possibly inhibiting angiogenesis and tumor growth through alterations in growth factor expression. (NCI04)

NCI-GLOSS Definition: An antibiotic drug used to treat infection. It belongs to the family of drugs called macrolides.

Display Name: Clarithromycin

Label: Clarithromycin

NCI Thesaurus Code: C1054 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0055856  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
6-O-Methylerythromycin
Abbott-56268
Biaxin
Clarithromycin
CLARITHROMYCIN
clarithromycin

External Source Codes: 
CAS Registry Number 81103-11-9 (see NLM ChemIDplus info)
FDA UNII Code H1250JIK0A
ChEBI ID CHEBI:3732 (see ChEBI info)
NSC Code 643733 (see NCI DTP info)
PDQ Closed Trial Search ID 42308
PDQ Open Trial Search ID 42308 (check for NCI PDQ open clinical trial info)
UMLS CUI C0055856

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For H. pylori infection; Various bacterial infections
Chemical_Formula C38H69NO13
code C1054
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Clarithromycin
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1054

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