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Version: 17.06d (Release date: 2017-06-26)
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Monocarboxylate Transporter 1 Inhibitor AZD3965 (Code C105399)

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Terms & Properties

Preferred Name: Monocarboxylate Transporter 1 Inhibitor AZD3965

Definition: An orally available inhibitor of monocarboxylate transporter 1 (MCT1), with potential antineoplastic activity. Upon oral administration, MCT1 inhibitor AZD3965 binds to MCT1 and prevents the transport of lactate into and out of the cell. This leads to an accumulation of lactate, intracellular acidification, and eventually cancer cell death. MCT1, a protein overexpressed on tumor cells, is responsible for the transport of monocarboxylates across the cell membrane and plays a key role in cell metabolism.

Label: Monocarboxylate Transporter 1 Inhibitor AZD3965

NCI Thesaurus Code: C105399 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3642150  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
MCT1 Inhibitor AZD3965
Monocarboxylate Transporter 1 Inhibitor AZD3965

External Source Codes: 
PDQ Closed Trial Search ID 746809
PDQ Open Trial Search ID 746809 (check for NCI PDQ open clinical trial info)
UMLS CUI C3642150

Other Properties:
     Name Value (qualifiers indented underneath)
code C105399
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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