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Version: 17.06d (Release date: 2017-06-26)
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Allogeneic T-Lymphocytes BPX-501 (Code C105395)

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Terms & Properties

Preferred Name: Allogeneic T-Lymphocytes BPX-501

Definition: Allogeneic, T-lymphocytes with potential immune reconstitution activity. Donor T-lymphocytes are transduced with a retroviral vector (BPZ-1001) encoding the inducible suicide gene caspase 9 (iCasp9) and linked to a drug binding domain. Donor T-cell therapy may help control transplant-related infections following allogeneic hematopoietic stem cell transplantation. However, the addition of donor T-cells can lead to graft-versus-host disease (GVHD). In the event that GVHD begins to develop, the chemical homodimerizer AP1903 can be administered, which binds to the drug binding domain and induces caspase 9 expression. This activates apoptosis in the T-cells causing GVHD.

Display Name: Allogeneic T-Lymphocytes BPX-501

Label: Allogeneic T-Lymphocytes BPX-501

NCI Thesaurus Code: C105395 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL446320  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Allogeneic T-Lymphocytes BPX-501

External Source Codes: 
PDQ Closed Trial Search ID 746804
PDQ Open Trial Search ID 746804 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C105395
Contributing_Source CTRP
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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