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Version: 17.12d (Release date: 2017-12-26)
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Phenethyl Isothiocyanate-containing Watercress Juice (Code C105392)

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Terms & Properties

Preferred Name: Phenethyl Isothiocyanate-containing Watercress Juice

Definition: A juice extracted from watercress containing high amounts of phenethyl isothiocyanate (PEITC), with potential chemopreventive and antitumor activities. Although the mechanism(s) of action through which PEITC exerts its effect(s) has yet to be fully elucidated, PEITC is able to induce apoptosis in tumor cells through the induction of reactive oxygen species (ROS). Additionally, PEITC is able to modulate extracellular signal-regulated kinases (ERK), c-Jun N-terminal kinase (JNK) and mitogen-activated protein kinase (MAPK) signal transduction pathways, activating the expression of stress-responsive genes and eventually inducing apoptosis. PEITC also inhibits the expression of genes involved in tumor progression such as HIF, STAT-3, HER2, BCL-XL, and XIAP and induces the expression of genes involved in tumor suppression such as p53, ATF-2, and p57. Furthermore, this agent has been shown to reactivate the gene expression of certain detoxification enzymes.

Label: Phenethyl Isothiocyanate-containing Watercress Juice

NCI Thesaurus Code: C105392 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL446318  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
PEITC-containing Watercress Juice
Phenethyl Isothiocyanate-containing Watercress Juice

External Source Codes: 
PDQ Closed Trial Search ID 746772
PDQ Open Trial Search ID 746772 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C105392
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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