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Version: 17.06d (Release date: 2017-06-26)
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Cathepsin-Activatable Cy5 Fluorescent Imaging Probe LUM015 (Code C105147)

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Terms & Properties

Preferred Name: Cathepsin-Activatable Cy5 Fluorescent Imaging Probe LUM015

Definition: A cathepsin-activatable fluorescent probe with imaging activity. The cathepsin-activatable fluorescent probe LUM015 contains the Cy5 fluorophore linked, via a pan-cathepsin protease cleavable peptide, to a fluorescent quencher. Upon injection, the peptide in LUM015 can be cleaved by cathepsins overexpressed by tumor cells, which releases the quencher and activates the fluorophore. Upon imaging, tumor cells expressing cathepsin family proteases can be detected.

Display Name: Cathepsin-Activatable Cy5 Fluorescent Imaging Probe LUM015

Label: Cathepsin-Activatable Cy5 Fluorescent Imaging Probe LUM015

NCI Thesaurus Code: C105147 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL446110  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Cathepsin-Activatable Cy5 Fluorescent Imaging Probe LUM015
LUM015

External Source Codes: 
PDQ Closed Trial Search ID 746336
PDQ Open Trial Search ID 746336 (check for NCI PDQ open clinical trial info)
NCI META CUI CL446110

Other Properties:
     Name Value (qualifiers indented underneath)
code C105147
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C105147

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