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Version: 17.06d (Release date: 2017-06-26)
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Chlorozotocin (Code C1049)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Chlorozotocin

Definition: A glucose-linked chloroethylnitrosourea with potential antineoplastic activity. Chlorozotocin alkylates DNA and proteins, induces the formation of interstrand DNA and DNA-protein crosslinks, and causes DNA strand breakage, thereby damaging DNA and resulting in cell death. This agent has been shown to exhibit antitumor and immunomodulatory effects in cell lines and animal models. Chlorozotocin is a mutagen and is less myelotoxic than other nitrosoureas. (NCI04)

Label: Chlorozotocin

NCI Thesaurus Code: C1049 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0055465  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1-(2-chloroethyl)-1-nitroso-3-(D-glucos-2-yl)urea
2-[3-(2-chloroethyl)-3-nitrosoureido]-2-deoxy-D-glucopyranose
2-[[[(2-chloroethyl)nitrosamino]carbonyl]amino]-2-deoxy-D-glucose
Chlorozotocin
CHLOROZOTOCIN
Chlorozotocyna
CHLZ
CZT
D-Glucopyranose
D-glucopyranose, 2-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]-2-deoxy
D-Glucopyranose, 2-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]-2-deoxy-
D-glucose, 2-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]-2-deoxy- (9CI)
D-Glucose, 2-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]-2-deoxy- (9CI)
DCNU

External Source Codes: 
CAS Registry Number 54749-90-5 (see NLM ChemIDplus info)
FDA UNII Code 3053LTY75Z
NSC Code 178248 (see NCI DTP info)
PDQ Closed Trial Search ID 39182
PDQ Open Trial Search ID 39182 (check for NCI PDQ open clinical trial info)
UMLS CUI C0055465

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C9H16ClN3O7
code C1049
Contributing_Source FDA
Legacy_Concept_Name Chlorozotocin
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1049

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