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Version: 17.12d (Release date: 2017-12-26)
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IGF-1R Inhibitor PL225B (Code C104746)

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Terms & Properties

Preferred Name: IGF-1R Inhibitor PL225B

Definition: An orally bioavailable inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic activity. IGF-1R inhibitor PL225B selectively binds to and inhibits the activities of IGF-1R, which may result in both the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis in IGF-1R-overexpressing tumor cells. IGF-1R, a receptor tyrosine kinase overexpressed in a variety of human cancers, plays a significant role in the stimulation of cellular proliferation, oncogenic transformation, and suppression of apoptosis.

Display Name: IGF-1R Inhibitor PL225B

Label: IGF-1R Inhibitor PL225B

NCI Thesaurus Code: C104746 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL445817  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
IGF-1R Inhibitor PL225B

External Source Codes: 
PDQ Closed Trial Search ID 746194
PDQ Open Trial Search ID 746194 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C104746
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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