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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Cancer Stemness Kinase Inhibitor BBI503 (Code C104745)

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Terms & Properties

Preferred Name: Cancer Stemness Kinase Inhibitor BBI503

Definition: An orally available cancer cell stemness kinase inhibitor with potential antineoplastic activity. Even though the exact target has not been fully elucidated, BBI503 targets and inhibits one or more pathways involved in cancer stem cell survival. As a result, cancer stem cell (CSC) growth as well as heterogeneous cancer cell growth is inhibited. CSCs, self-replicating cells able to differentiate into heterogeneous cancer cells, appear to be responsible for both tumor relapse and metastasis.

Display Name: Cancer Stemness Kinase Inhibitor BBI503

Label: Cancer Stemness Kinase Inhibitor BBI503

NCI Thesaurus Code: C104745 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL445816  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Cancer Stemness Kinase Inhibitor BBI503

External Source Codes: 
PDQ Closed Trial Search ID 746133
PDQ Open Trial Search ID 746133 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C104745
Contributing_Source CTRP
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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