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Version: 17.06d (Release date: 2017-06-26)
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Ulixertinib (Code C104744)

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Terms & Properties

Preferred Name: Ulixertinib

Definition: An orally available inhibitor of extracellular signal-regulated kinase (ERK) 1 and 2, with potential antineoplastic activity. Upon oral administration, BVD-523 inhibits both ERK 1 and 2, thereby preventing the activation of ERK-mediated signal transduction pathways. This results in the inhibition of ERK-dependent tumor cell proliferation and survival. The mitogen-activated protein kinase (MAPK)/ERK pathway is often upregulated in a variety of tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival.

Display Name: Ulixertinib

Label: Ulixertinib

NCI Thesaurus Code: C104744 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL445815  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1H-Pyrrole-2-carboxamide, 4-(5-chloro-2-((1-methylethyl)amino)-4-pyridinyl)-N-((1S)-1-(3-chlorophenyl)-2-hydroxyethyl)-
BVD-523
Ulixertinib
ULIXERTINIB
VRT752271

External Source Codes: 
CAS Registry Number 869886-67-9 (see NLM ChemIDplus info)
FDA UNII Code 16ZDH50O1U
PDQ Closed Trial Search ID 746054
PDQ Open Trial Search ID 746054 (check for NCI PDQ open clinical trial info)
NCI META CUI CL445815

Other Properties:
     Name Value (qualifiers indented underneath)
code C104744
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C104744

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