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Version: 17.06d (Release date: 2017-06-26)
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WT1 247-261 Peptide Vaccine (Code C104737)

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Terms & Properties

Preferred Name: WT1 247-261 Peptide Vaccine

Definition: A synthetic peptide vaccine consisting of a HLA-DRw53-restricted human Wilms' Tumor protein-1 (WT1) peptide comprised of amino acids 247 through 261, a HLA class II-restricted WT1 peptide, with potential immunomodulating and antitumor activities. Vaccination with WT1 247-261 peptide may stimulate a CD4-positive helper T-lymphocyte-mediated immune response against WT1 expressing cells. Activated helper T-cells stimulate dendritic cells, and activate the proliferation of other T-lymphoctes and B-lymphocytes. This causes tumor cell lysis and inhibition of cancer cell proliferation in WT1-overexpressing tumor cells. WT1, a zinc finger DNA-binding protein, is overexpressed in most types of leukemia and in a variety of solid cancers.

Display Name: WT1 247-261 Peptide Vaccine

Label: WT1 247-261 Peptide Vaccine

NCI Thesaurus Code: C104737 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL445810  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
WT1 247-261 Peptide Vaccine

External Source Codes: 
PDQ Closed Trial Search ID 746009
PDQ Open Trial Search ID 746009 (check for NCI PDQ open clinical trial info)
NCI META CUI CL445810

Other Properties:
     Name Value (qualifiers indented underneath)
code C104737
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C104737

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