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Version: 17.06d (Release date: 2017-06-26)
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Volitinib (Code C104732)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Volitinib

Definition: An orally bioavailable inhibitor of the c-Met receptor tyrosine kinase with potential antineoplastic activity. Volitinib selectively binds to and inhibits the activation of c-Met in an ATP-competitive manner, and disrupts c-Met signal transduction pathways. This may result in cell growth inhibition in tumors that overexpress the c-Met protein. C-Met encodes the hepatocyte growth factor receptor tyrosine kinase and plays an important role in tumor cell proliferation, survival, invasion, and metastasis, and tumor angiogenesis; this protein is overexpressed or mutated in a variety of cancers.

Label: Volitinib

NCI Thesaurus Code: C104732 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3642466  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AZD6094
HMPL-504
SAVOLITINIB
Volitinib

External Source Codes: 
FDA UNII Code 2A2DA6857R
PDQ Closed Trial Search ID 745761
PDQ Open Trial Search ID 745761 (check for NCI PDQ open clinical trial info)
UMLS CUI C3642466

Other Properties:
     Name Value (qualifiers indented underneath)
code C104732
Contributing_Source FDA
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C104732

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