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Version: 17.06d (Release date: 2017-06-26)
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Technetium Tc 99 Hydrazinonicotinamide-Tricine-linked Interleukin-2 (Code C104731)

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Terms & Properties

Preferred Name: Technetium Tc 99 Hydrazinonicotinamide-Tricine-linked Interleukin-2

Definition: A radioconjugate composed of the cytokine interleukin-2 (IL-2) conjugated to the bifunctional chelating agent succinimidyl-6-hydrazinopyridine-3-carboxylate (HYNIC-NHS) and co-ligand tricine and labeled with the radioisotope technetium Tc 99m (99mTc-HYNIC-IL2), that can potentially be used as a diagnostic agent to detect tumor inflammation. Upon intravenous administration, IL-2 selectively binds to the IL-2 receptor (IL-2R) expressed on tumor infiltrating lymphocytes (TILs); upon internalization, the Tc99m moiety can be visualized using radioimaging, which allows the quantification of TILs expressing IL-2R. This agent detects tumor enlargement due to invasion by TILs and not tumor progression.

Display Name: Technetium Tc 99 Hydrazinonicotinamide-Tricine-linked Interleukin-2

Label: Technetium Tc 99 Hydrazinonicotinamide-Tricine-linked Interleukin-2

NCI Thesaurus Code: C104731 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL445806  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
99mTc-HYNIC-IL2
Technetium Tc 99 Hydrazinonicotinamide-Tricine-linked Interleukin-2

External Source Codes: 
PDQ Closed Trial Search ID 745755
PDQ Open Trial Search ID 745755 (check for NCI PDQ open clinical trial info)
NCI META CUI CL445806

Other Properties:
     Name Value (qualifiers indented underneath)
code C104731
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C104731

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