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Version: 17.06d (Release date: 2017-06-26)
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Fadrozole Hydrochloride (Code C1044)

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Terms & Properties

Preferred Name: Fadrozole Hydrochloride

Definition: The hydrochloride salt of the nonsteroidal aromatase inhibitor fadrozole with potential antineoplastic activity. Fadrozole specifically inhibits aromatase, blocking the aromatization of androstenedione and testosterone into estrone and estradiol, respectively, the final step in estrogen biosynthesis; the reduction in estrogen levels may inhibit growth in estrogen-dependent cancers. Aromatase, a member of the cytochrome P-450 superfamily, is found in many tissues; overexpression has been linked to the development of preneoplastic and neoplastic changes in breast tissue.

Label: Fadrozole Hydrochloride

NCI Thesaurus Code: C1044 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0917743  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4-(5,6,7,8-Tetrahydroimidazo(1,5-a)pyridin-5-yl)benzonitrile Hydrochloride
4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile Monohydrochloride
Afema
Arensin
CGS-16949A
Fadrozole Hydrochloride
FADROZOLE HYDROCHLORIDE

External Source Codes: 
CAS Registry Number 102676-31-3 (see NLM ChemIDplus info)
CAS Registry Number 102676-96-0 (see NLM ChemIDplus info)
FDA UNII Code H0Q44H4ECQ
PDQ Closed Trial Search ID 41025
PDQ Open Trial Search ID 41025 (check for NCI PDQ open clinical trial info)
UMLS CUI C0917743

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C14H13N3.HCl
code C1044
Contributing_Source FDA
Legacy_Concept_Name Fadrozole_Hydrochloride
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1044

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