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Version: 17.06d (Release date: 2017-06-26)
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PI3K/mTOR/ALK-1/DNA-PK Inhibitor P7170 (Code C104292)

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Terms & Properties

Preferred Name: PI3K/mTOR/ALK-1/DNA-PK Inhibitor P7170

Definition: An orally bioavailable inhibitor of phosphoinositide 3-kinase (PI3K), mammalian target of rapamycin (mTOR), activin receptor-like kinase 1 (ALK-1) and DNA-dependent protein kinase (DNA-PK), with potential anti-angiogenic and antineoplastic activities. Upon oral administration, PI3K/mTOR/ALK-1/DNA-PK inhibitor P7170 inhibits the activity of all four kinases. This prevents PI3K/mTOR and ALK-1-mediated signaling pathways and may lead to the inhibition of cancer cell growth in PI3K/mTOR-overexpressing tumor cells and angiogenesis in ALK-1-overexpressing endothelial cells. Also, by inhibiting DNA-PK, this agent inhibits the ability of tumor cells to repair damaged DNA. The PI3K/mTOR pathway is upregulated in a variety of tumors and plays an important role in regulating cancer cell proliferation, growth, and survival. ALK-1, a member of the transforming growth factor beta (TGF-b) type I receptor family, is overexpressed on endothelial cells in a variety of tumor types and increases endothelial cell proliferation and migration. DNA-PK is activated upon DNA damage and plays a key role in repairing double-stranded DNA breaks.

Display Name: PI3K/mTOR/ALK-1/DNA-PK Inhibitor P7170

Label: PI3K/mTOR/ALK-1/DNA-PK Inhibitor P7170

NCI Thesaurus Code: C104292 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL445627  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
P7170
PI3K/mTOR/ALK-1/DNA-PK Inhibitor P7170

External Source Codes: 
PDQ Closed Trial Search ID 745036
PDQ Open Trial Search ID 745036 (check for NCI PDQ open clinical trial info)
NCI META CUI CL445627

Other Properties:
     Name Value (qualifiers indented underneath)
code C104292
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C104292

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