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Version: 17.06d (Release date: 2017-06-26)
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p53/HDM2 Interaction Inhibitor CGM097 (Code C104280)

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Terms & Properties

Preferred Name: p53/HDM2 Interaction Inhibitor CGM097

Definition: An orally bioavailable HDM2 (human homolog of double minute 2) antagonist with potential antineoplastic activity. Upon oral administration, p53/HDM2 interaction inhibitor CGM097 inhibits the binding of the HDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this HDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited, which may result in the restoration of p53 signaling and, thus, the p53-mediated induction of tumor cell apoptosis. HDM2, a zinc finger nuclear phosphoprotein, is a negative regulator of the p53 pathway, often overexpressed in cancer cells and has been implicated in cancer cell proliferation and survival.

Display Name: p53/HDM2 Interaction Inhibitor CGM097

Label: p53/HDM2 Interaction Inhibitor CGM097

NCI Thesaurus Code: C104280 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL445618  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CGM097
HDM2/p53 Inhibitor CGM097
p53/HDM2 Interaction Inhibitor CGM097

External Source Codes: 
PDQ Closed Trial Search ID 744999
PDQ Open Trial Search ID 744999 (check for NCI PDQ open clinical trial info)
NCI META CUI CL445618

Other Properties:
     Name Value (qualifiers indented underneath)
code C104280
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C104280

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