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Version: 17.06d (Release date: 2017-06-26)
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Fluorine F 18-labeled S-(3-Fluoropropyl)homocysteine Hydrochloride (Code C104269)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Fluorine F 18-labeled S-(3-Fluoropropyl)homocysteine Hydrochloride

Definition: The hydrochloride salt form of a radioconjugate composed of a synthetic derivative of the amino acid methionine radiolabeled with fluoride F 18, with potential use as a tumor imaging agent during positron emission tomography (PET). Upon administration, fluorine F 18-labeled S-(3-fluoropropyl) homocysteine is preferentially taken up by tumor cells through an amino acid transporter, which is overexpressed by cancer cells. As tumor cells have a higher rate of proliferation than normal cells, these cancer cells have increased rates of protein synthesis and thus an increased demand for amino acids. This allows for visualization of tumors cells upon PET.

Label: Fluorine F 18-labeled S-(3-Fluoropropyl)homocysteine Hydrochloride

NCI Thesaurus Code: C104269 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL445614  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
18F-FPM
[(18)F]FPHCys
Fluorine F 18-labeled S-(3-Fluoropropyl)homocysteine Hydrochloride

External Source Codes: 
PDQ Closed Trial Search ID 744815
PDQ Open Trial Search ID 744815 (check for NCI PDQ open clinical trial info)
NCI META CUI CL445614

Other Properties:
     Name Value (qualifiers indented underneath)
code C104269
Semantic_Type Indicator, Reagent, or Diagnostic Aid
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C104269

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