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Version: 17.06d (Release date: 2017-06-26)
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pan FGFR Inhibitor ARQ 087 (Code C104267)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: pan FGFR Inhibitor ARQ 087

Definition: An orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) with potential antineoplastic activity. FGFR inhibitor ARQ 087 binds to and potently inhibits the activity of FGFR subtypes 1, 2 and 3. This may result in the inhibition of FGFR-mediated signal transduction pathways, tumor cell proliferation, tumor angiogenesis and tumor cell death in FGFR-overexpressing tumor cells. FGFR, a receptor tyrosine kinase, is upregulated in many tumor cell types and plays a key role in tumor cellular proliferation, differentiation, angiogenesis and survival.

Display Name: pan FGFR Inhibitor ARQ 087

Label: pan FGFR Inhibitor ARQ 087

NCI Thesaurus Code: C104267 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL445613  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ARQ 087
pan FGFR Inhibitor ARQ 087

External Source Codes: 
ChEBI ID CHEBI:63453 (see ChEBI info)
PDQ Closed Trial Search ID 744652
PDQ Open Trial Search ID 744652 (check for NCI PDQ open clinical trial info)
NCI META CUI CL445613

Other Properties:
     Name Value (qualifiers indented underneath)
code C104267
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C104267

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