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Version: 17.06d (Release date: 2017-06-26)
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Cefepime Hydrochloride (Code C1041)

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Terms & Properties

Preferred Name: Cefepime Hydrochloride

Definition: The hydrochloride salt of a semi-synthetic, beta-lactamase-resistant, fourth-generation cephalosporin antibiotic derived from an Acremonium fungal species with broad-spectrum bactericidal activity. Administered parenterally, cefepime inhibits bacterial cell wall synthesis by binding to and inactivating penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity, resulting in a reduction of bacterial cell wall stability and cell lysis. This agent is more active against a variety of Gram-positive pathogens compared to third-generation cephalosporins.

Display Name: Cefepime Hydrochloride

Label: Cefepime Hydrochloride

NCI Thesaurus Code: C1041 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0771284  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Cefepime Hydrochloride
CEFEPIME HYDROCHLORIDE
Maxipime
Pyrrolidinium, 1-((7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-1-methyl-, hydroxide, inner salt, (6R-(6alpha,7beta(Z)))-

External Source Codes: 
CAS Registry Number 123171-59-5 (see NLM ChemIDplus info)
FDA UNII Code I8X1O0607P
ChEBI ID CHEBI:31368 (see ChEBI info)
PDQ Closed Trial Search ID 38350
PDQ Open Trial Search ID 38350 (check for NCI PDQ open clinical trial info)
UMLS CUI C0771284

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Upper respiratory tract and urinary tract infections; febrile neutropenic conditions
Chemical_Formula C19H24N6O5S2.2ClH.H2O
code C1041
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Cefepime
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1041

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