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Version: 17.06d (Release date: 2017-06-26)
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Telapristone Acetate (Code C104055)

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Terms & Properties

Preferred Name: Telapristone Acetate

Definition: The acetate form of the 21-substituted-19-nor-progestin telapristone, an orally available selective progesterone receptor modulator (SPRM), with potential anti-progesterone and antineoplastic activities. Upon oral administration, CDB-4124 competitively binds to the progesterone receptor (PR) in progesterone-responsive tissue and inhibits PR-mediated gene expression. This interferes with progesterone activity in the reproductive system. As a result, this agent may suppress ovulation and inhibit proliferation of endometrial tissue. Also, this agent may prevent cell growth and induce apoptosis in estrogen receptor (ER) and PR-positive breast cancer cells through a reduction in progesterone levels, ER downregulation and a suppression of the expression of cyclin-dependent kinases (CDK) 2 and 4, ultimately leading to G1/S cell cycle arrest. Unlike some other SPRMs, this agent does not exert any estrogenic, androgenic, anti-estrogenic, and anti-androgenic activities.

Display Name: Telapristone Acetate

Label: Telapristone Acetate

NCI Thesaurus Code: C104055 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3501648  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(8S,11R,13S,14S,17R)-11-(4-(Dimethylamino)phenyl)-17-(2-methoxyacetyl)-13-methyl-3-oxo-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl Acetate
Telapristone Acetate

External Source Codes: 
PDQ Closed Trial Search ID 598776
PDQ Open Trial Search ID 598776 (check for NCI PDQ open clinical trial info)
UMLS CUI C3501648

Other Properties:
     Name Value (qualifiers indented underneath)
code C104055
Contributing_Source CTRP
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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