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Version: 17.06d (Release date: 2017-06-26)
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Zirconium Zr 89-labeled RO5479599 (Code C104010)

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Terms & Properties

Preferred Name: Zirconium Zr 89-labeled RO5479599

Definition: A radioimmunoconjugate containing a glycoengineered, humanized monoclonal antibody directed against the human epidermal growth factor receptor HER3 (ErbB3) and labeled with the radioisotope zirconium Zr 89, with radioisotopic activity and potential use as an imaging agent as well as potential antineoplastic activity. Upon administration, the RO5479599 moiety of zirconium Zn 89-labeled RO5479599 binds to the extracellular domain of HER3 and inhibits HER3 dimerization, thereby preventing EGFR-dependent signaling. In addition, RO5479599 elicits enhanced antibody-dependent cellular cytotoxicity (ADCC). Upon binding, the radioisotope moiety may be detected using positron emission tomography (PET), thereby allowing the imaging and quantification of HER3-expressing tumor cells. HER3, a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases, is frequently overexpressed in tumors; it has no active kinase domain but is activated through heterodimerization with other members of the EGFR receptor family, such as HER2.

Label: Zirconium Zr 89-labeled RO5479599

NCI Thesaurus Code: C104010 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL438392  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
89Zr-labeled RO5479599
89Zr-RO5479599
Zirconium Zr 89-labeled RO5479599

External Source Codes: 
PDQ Closed Trial Search ID 744006
PDQ Open Trial Search ID 744006 (check for NCI PDQ open clinical trial info)
NCI META CUI CL438392

Other Properties:
     Name Value (qualifiers indented underneath)
code C104010
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C104010

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