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Version: 17.06d (Release date: 2017-06-26)
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PI3K/HDAC Inhibitor CUDC-907 (Code C104008)

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Terms & Properties

Preferred Name: PI3K/HDAC Inhibitor CUDC-907

Definition: An orally bioavailable inhibitor of both phosphoinositide 3-kinase (PI3K) class I and pan histone deacetylase (HDAC) enzymes, with potential antineoplastic activity. Upon oral administration, CUDC-907 inhibits the activity of both PI3K class I isoforms and HDAC, thereby preventing the activation of the PI3K-AKT-mTOR signal transduction pathway that is often overactivated in many cancer cell types. This may prevent growth of PI3K and/or HDAC-expressing tumor cells. CUDC-907 shows an increased inhibition of tumor cell growth and induction of apoptosis when compared to inhibitors that target either PI3K or HDAC.

Display Name: PI3K/HDAC Inhibitor CUDC-907

Label: PI3K/HDAC Inhibitor CUDC-907

NCI Thesaurus Code: C104008 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3530053  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CUDC-907
PI3K/HDAC Inhibitor CUDC-907

External Source Codes: 
PDQ Closed Trial Search ID 743908
PDQ Open Trial Search ID 743908 (check for NCI PDQ open clinical trial info)
UMLS CUI C3530053

Other Properties:
     Name Value (qualifiers indented underneath)
code C104008
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C104008

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