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Version: 17.06d (Release date: 2017-06-26)
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PI3K Alpha/Beta Inhibitor BAY1082439 (Code C103861)

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Terms & Properties

Preferred Name: PI3K Alpha/Beta Inhibitor BAY1082439

Definition: An orally bioavailable inhibitor of the class I phosphoinositide 3-kinase (PI3K) alpha and beta isoforms with potential antineoplastic activity. PI3K alpha/beta inhibitor BAY1082439 selectively inhibits both PI3K alpha, including mutated forms of PIK3CA, and PI3K beta in the PI3K/Akt/mTOR pathway, which may result in tumor cell apoptosis and growth inhibition in PI3K-expressing and/or PTEN-driven tumor cells. By specifically targeting class I PI3K alpha and beta, this agent may be more efficacious and less toxic than pan PI3K inhibitors. Dysregulation of the PI3K/Akt/mTOR pathway is frequently found in solid tumors and results in increased tumor cell growth, survival, and resistance to chemotherapy and radiotherapy. PIK3CA, one of the most highly mutated oncogenes, encodes the p110-alpha catalytic subunit of the class I PI3K. PTEN, a tumor suppressor protein and negative regulator of PI3K activity, is often mutated in a variety of cancer cells.

Label: PI3K Alpha/Beta Inhibitor BAY1082439

NCI Thesaurus Code: C103861 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL438339  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
BAY1082439
PI3K Alpha/Beta Inhibitor BAY1082439

External Source Codes: 
PDQ Closed Trial Search ID 743262
PDQ Open Trial Search ID 743262 (check for NCI PDQ open clinical trial info)
NCI META CUI CL438339

Other Properties:
     Name Value (qualifiers indented underneath)
code C103861
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C103861

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